A new class of anti-HIV agents: synthesis and activity of conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor

T Kimura; H Matsumoto; T Matsuda; T Hamawaki; K Akaji; Y Kiso

doi:10.1016/s0960-894x(99)00089-x

A new class of anti-HIV agents: synthesis and activity of conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor

Bioorg Med Chem Lett. 1999 Mar 22;9(6):803-6. doi: 10.1016/s0960-894x(99)00089-x.

Authors

T Kimura¹, H Matsumoto, T Matsuda, T Hamawaki, K Akaji, Y Kiso

Affiliation

¹ Department of Medicinal Chemistry, Kyoto Pharmaceutical University, Japan.

PMID: 10206539
DOI: 10.1016/s0960-894x(99)00089-x

Abstract

Conjugates of HIV protease inhibitors with a reverse transcriptase inhibitor were synthesized, which expressed excellent antiviral activity compared with that of the individual components. The remarkable antiviral activity of the conjugated compounds may be due to their penetration into the cell and later splitting into two different classes of anti-HIV agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / administration & dosage*
Anti-HIV Agents / chemical synthesis
Drug Combinations
HIV Protease Inhibitors / chemical synthesis*
Models, Chemical
Reverse Transcriptase Inhibitors / chemical synthesis*
Zidovudine / chemistry

Substances

Anti-HIV Agents
Drug Combinations
HIV Protease Inhibitors
Reverse Transcriptase Inhibitors
Zidovudine